New CRISPR Tool Gives Scientists Control Over Cellular Protein Production
Reported bySciTechDaily ↗·Sourced by Goodlede
Researchers at LMU and Helmholtz Munich developed TAPIR, a CRISPR-based method that increases ribosomal RNA production to directly control protein synthesis. In mouse models of Treacher-Collins syndrome, targeted rRNA stimulation partially compensated for disease-linked changes, and the same mechanism showed potential for limiting pancreatic cancer growth by restricting the protein supply tumors need.
The findings are limited to mouse models.
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