Study finds sustained benefit for people using Oregon psilocybin services

346 people who took a single psilocybin session at one of 24 licensed Oregon service centres reported lower depression, anxiety and PTSD symptoms three months on, with 91.5% saying they benefited and 64.9% ranking it among the ten most meaningful experiences of their life. Published in JAMA Network Open, it is the first multisite study of the legal market Oregon voters approved in 2020.

This tracked people who chose the service and reported on themselves, rather than a controlled trial, so it cannot prove psilocybin caused the change. About half the participants did not have moderate to severe depression to begin with. The researchers say psilocybin is not suitable for people with psychosis or bipolar disorder, or during pregnancy.