Scientists Discover How Exercise Could Help Protect the Brain From Parkinson's

A review of 129 studies shows that contracting muscles release chemical messengers called exerkines—including BDNF, IGF-1, irisin, and cathepsin B—that can travel through the bloodstream and help vulnerable dopamine-producing nerve cells resist damage, potentially reducing inflammation, oxidative stress, and supporting neuroplasticity.

The review synthesizes preclinical and animal research; further clinical trials are needed to establish whether these mechanisms meaningfully slow neurodegeneration in people with Parkinson's disease.